In htaccess, is a redirect of "/index.php?main_page=" to "" safe?

In htaccess, is a redirect of "/index.php?main_page=" to "" safe?

I have migrated to a new PHP CMS that has redirects, but the old site used
the convention...
/index.php?main_page=
frequently. Would it be possible to alter this in htaccess without risking
issues, that for example might redirect the same code on the admin I might
not be aware of?